• Choose your poison – Space-use strategy influences pollutant exposure in Barents Sea polar bears 

      Tartu, Sabrina; Aars, Jon; Andersen, Magnus; Polder, Anuschka; Bourgeon, Sophie; Merkel, Benjamin; Lowther, Andrew D.; Bytingsvik, Jenny; Welker, Jeffrey Martin; Derocher, Andrew E.; Jenssen, Bjørn Munro; Routti, Heli (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-24)
      Variation in space-use is common within mammal populations. In polar bears, Ursus maritimus, some individuals follow the sea ice (offshore bears) whereas others remain nearshore yearlong (coastal bears). We studied pollutant exposure in relation to space-use patterns (offshore vs coastal) in adult female polar bears from the Barents Sea equipped with satellite collars (2000–2014, n = 152). First, ...
    • Current state of knowledge on biological effects from contaminants on arctic wildlife and fish 

      Dietz, Rune; Letcher, Robert J.; Desforges, Jean-Pierre; Eulaers, Igor; Sonne, Christian; Wilson, Simon; Andersen-Ranberg, Emilie; Basu, Niladri; Barst, Benjamin D.; Bustnes, Jan Ove; Bytingsvik, Jenny; Ciesielski, Tomasz Maciej; Drevnick, Paul E.; Gabrielsen, Geir W.; Haarr, Ane; Hylland, Ketil; Jenssen, Bjørn Munro; Levin, Milton; McKinney, Melissa A.; Nørregaard, Rasmus Dyrmose; Pedersen, Kathrine E.; Provencher, Jennifer; Styrishave, Bjarne; Tartu, Sabrina; Aars, Jon; Ackerman, Joshua T.; Rosing-Asvid, Aqqalu; Barrett, Rob; Bignert, Anders; Born, Erik W; Branigan, Marsha; Braune, Birgit; Bryan, Colleen E; Dam, Maria; Eagles-Smith, Collin A.; Evans, Marlene; Evans, Thomas J.; Fisk, Aaron T.; Gamberg, Mary; Gustavson, Kim; Hartman, C. Alex; Helander, Björn; Herzog, Mark P.; Hoekstra, Paul F.; Houde, Magali; Hoydal, Katrin; Jackson, Allyson K.; Kucklick, John; Lie, Elisabeth; Loseto, Lisa; Mallory, Mark L.; Miljeteig, Cecilie; Mosbech, Anders; Muir, Derek C.G.; Nielsen, Sanna Túni; Peacock, Elizabeth; Pedro, Sara; Peterson, Sarah H.; Polder, Anuschka; Rigét, Frank F.; Roach, Pat; Saunes, Halvor; Sinding, Mikkel Holger Strander; Skåre, Janneche Utne; Søndergaard, Jens; Stenson, Garry; Stern, Gary; Treu, Gabriele; Schuur, Stacy S.; Víkingsson, Gísli Arnór (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-13)
      Since the last Arctic Monitoring and Assessment Programme (AMAP) effort to review biological effects of the exposure to organohalogen compounds (OHCs) in Arctic biota, there has been a considerable number of new Arctic effect studies. Here, we provide an update on the state of the knowledge of OHC, and also include mercury, exposure and/or associated effects in key Arctic marine and terrestrial ...
    • Diet and metabolic state are the main factors determining concentrations of perfluoroalkyl substances in female polar bears from Svalbard 

      Tartu, Sabrina; Bourgeon, Sophie; Aars, Jon; Andersen, Magnus; Lone, Karen; Jenssen, Bjørn Munro; Polder, Anuschka; Thiemann, Gregory W.; Torget, Vidar; Welker, Jeffrey Martin; Routti, Heli Anna Irmeli (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-03)
      Perfluoroalkyl substances (PFASs) have been detected in organisms worldwide, including Polar Regions. The polar bear (Ursus maritimus), the top predator of Arctic marine ecosystems, accumulates high concentrations of PFASs, which may be harmful to their health. The aim of this study was to investigate which factors (habitat quality, season, year, diet, metabolic state [i.e. feeding/fasting], breeding ...
    • Homology modeling to screen for potential binding of contaminants to thyroid hormone receptor and transthyretin in glaucous gull (Larus hyperboreus) and herring gull (Larus argentatus) 

      Mortensen, Åse-Karen; Mæhre, Silje; Kristiansen, kurt; Heimstad, Eldbjørg Sofie; Gabrielsen, Geir W.; Jenssen, Bjørn Munro; Sylte, Ingebrigt (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-11)
      Thyroid hormone disrupting chemicals (THDCs) are of major concern in ecotoxicology. With the increased number of emerging chemicals on the market there is a need to screen for potential THDCs in a cost-efficient way, and <i>in silico</i> modeling is an alternative to address this issue. In this study homology modeling and docking was used to screen a list of 626 compounds for potential thyroid hormone ...
    • In Vitro and in Silico Competitive Binding of Brominated Polyphenyl Ether Contaminants with Human and Gull Thyroid Hormone Transport Proteins 

      Hill, Katie L.; Mortensen, Åse-Karen; Teclechiel, Daniel; Willmore, William G.; Sylte, Ingebrigt; Jenssen, Bjørn Munro; Letcher, Robert James (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-28)
      Tetradecabromo-1,4-diphenoxybenzene (TeDB-DiPhOBz) is a highly brominated additive flame retardant (FR). Debrominated photodegradates of TeDBDiPhOBz are hydroxylated <i>in vitro</i> in liver microsomal assays based on herring gulls (<i>Larus argentatus</i>), including one metabolite identified as 4<i>″</i>-OH-2,2<i>′</i>,2<i>″</i>,4-tetrabromo-DiPhOBz. Chemically related methoxylated tetra- ...
    • Mandibular shape in farmed Arctic foxes (Vulpes lagopus) exposed to persistent organic pollutants 

      Bradley, Madison M.; Perra, Megan; Ahlstrøm, Øystein; Jenssen, Bjørn Munro; Jørgensen, Even Hjalmar; Fuglei, Eva; Muir, Derek C.G.; Sonne, Christian (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-26)
      We investigated if dietary exposure to persistent organic pollutants (POPs) affect mandibular asymmetry and periodontal disease in paired male-siblings of Arctic foxes (<i>Vulpes lagopus</i>). During ontogeny, one group of siblings was exposed to the complexed POP mixture in naturally contaminated minke whale (<i>Balaenoptere acutorostarta</i>) blubber (n = 10), while another group was given wet ...
    • Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears 

      Tartu, Sabrina; Lille-Langøy, Roger; Størseth, Trond Røvik; Bourgeon, Sophie; Brunsvik, Anders; Goksøyr, Anders; Jenssen, Bjørn Munro; Polder, Anuschka; Thiemann, Gregory W.; Torget, Vidar; Routti, Heli (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-28)
      There is growing evidence from experimental and human epidemiological studies that many pollutants can disrupt lipid metabolism. In Arctic wildlife, the occurrence of such compounds could have serious consequences for seasonal feeders. We set out to study whether organohalogenated compounds (OHCs) could cause disruption of energy metabolism in female polar bears ( Ursus maritimus ) from ...
    • Phthalate metabolites in harbor porpoises (Phocoena phocoena) from Norwegian coastal waters 

      Rian, May Britt; Vike-Jonas, Kristine; Gonzalez, Susana Villa; Ciesielski, Tomasz Maciej; Venkatraman, Vishwesh; Lindstrøm, Ulf; Jenssen, Bjørn Munro; Asimakopoulos, Alexandros (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-03)
      The exposure of marine mammals to phthalates has received considerable attention due to the ubiquitous occurrence of these pollutants in the marine environment and their potential adverse health effects. The occurrence of phthalate metabolites is well established in human populations, but data is scarce for marine mammals. In this study, concentrations of 17 phthalate metabolites were determined in ...
    • Potentiation of ecological factors on the disruption of thyroid hormones by organo-halogenated contaminants in female polar bears (Ursus maritimus) from the Barents Sea. 

      Bourgeon, Sophie; Riemer, Astrid Kolind; Tartu, Sabrina; Aars, Jon; Polder, Anuschka; Jenssen, Bjørn Munro; Routti, Heli Anna Irmeli (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-11)
      As apex predators, polar bears (Ursus maritimus) are among the most heavily polluted organisms in the Arctic. In addition to this anthropogenic stressor, climate warming has been shown to negatively affect their body condition, reproductive output and survival. Among potential underlying physiological mechanisms, thyroid hormones (THs), which control thermoregulation, metabolism and reproduction, ...
    • Prevalence of antibodies against Brucella spp. in West Greenland polar bears (Ursus maritimus) and East Greenland muskoxen (Ovibos moschatus) 

      Sonne, Christian; Andersen-Ranberg, Emilie; Rajala, Elisabeth; Agerholm, Jørgen S.; Bonefeld-Jørgensen, Eva; Desforges, Jean-Pierre; Eulaers, Igor; Gustavson, Kim; Jenssen, Bjørn Munro; Koch, Anders; Rosing-Asvid, Aqqalu; Schmidt, Nils Martin; Grøndahl, Carsten; Mosbacher, Jesper Bruun; Siebert, Ursula; Tryland, Morten; Mulvad, Gert; Born, Erik W; Laidre, Kristin; Wiig, Øystein; Dietz, Rune; Magnusson, Ulf (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-19)
      Zoonotic infections transmitted from terrestrial and marine mammals to humans in European Arctic are of unknown significance, despite considerable potential for transmission due to local hunt and a rapidly changing environment. As an example, infection with <i>Brucella</i> bacteria may have significant impact on human health due to consumption of raw meat or otherwise contact with tissues and fluids ...
    • Rapid Determination of Per- and Polyfluoroalkyl Substances (PFAS) in Harbour Porpoise Liver Tissue by HybridSPE®–UPLC®–MS/MS 

      Trimmel, Simone; Vike-Jonas, Kristine; Gonzalez, Susana Villa; Ciesielski, Tomasz Maciej; Lindstrøm, Ulf; Jenssen, Bjørn Munro; Asimakopoulos, Alexandros (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-01)
      A rapid hybrid solid phase extraction (HybridSPE®) protocol tailored to ultra-performance liquid chromatography–electrospray ionization tandem mass spectrometry (UPLC®–ESI–MS/MS) analysis was developed for the determination of 15 per- and polyfluoroalkyl substances (PFAS) in liver tissue from harbour porpoises (Phocoena phocoena). The HybridSPE® technique has been applied in trace concentration ...
    • A risk assessment of the effects of mercury on Baltic Sea, Greater North Sea and North Atlantic wildlife, fish and bivalves 

      Dietz, Rune; Fort, Jérôme; Sonne, Christian; Albert, Céline; Bustnes, Jan Ove; Christensen, Thomas Kjær; Ciesielski, Tomasz Maciej; Danielsen, Jóhannis; Dastnai, Sam; Eens, Marcel; Erikstad, Kjell E; Galatius, Anders; Garbus, Svend-Erik; Gilg, Oliver; Hanssen, Sveinn Are; Helander, Björn; Helberg, Morten; Jaspers, Veerle; Jenssen, Bjørn Munro; Jónsson, Jón Einar; Kauhala, Kaarina; Kolbeinsson, Yann; Kyhn, Line A.; Labansen, Aili Lage; Larsen, Martin M.; Lindstrøm, Ulf; Reiertsen, Tone Kristin; Rigét, Frank F.; Roos, Anna; Strand, Jakob; Strøm, Hallvard; Søndergaard, Jens; Sun, Jiachen; Teilmann, Jonas; Therkildsen, Ole Roland; Thórarinsson, Thorkell Lindberg; Tjørnløv, Rune Skjold; Wilson, Simon; Eulaers, Igor (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-24)
      A wide range of species, including marine mammals, seabirds, birds of prey, fish and bivalves, were investigated for potential population health risks resulting from contemporary (post 2000) mercury (Hg) exposure, using novel risk thresholds based on literature and de novo contamination data. The main geographic focus is on the Baltic Sea, while data from the same species in adjacent waters, such ...
    • A risk assessment review of mercury exposure in Arctic marine and terrestrial mammals 

      Dietz, Rune; Letcher, Robert J.; Aars, Jon; Andersen, Magnus; Boltunov, Andrei; Born, Erik W.; Ciesielski, Tomasz Maciej; Das, Krishna; Dastnai, Sam; Derocher, Andrew E.; Desforges, Jean-Pierre; Eulaers, Igor; Ferguson, Steve; Hallanger, Ingeborg G.; Heide-Jørgensen, Mads P.; Heimbürger-Boavida, Lars-Eric; Hoekstra, Paul F.; Jenssen, Bjørn Munro; Kohler, Stephen Gustav; Larsen, Martin M.; Lindstrøm, Ulf Ove; Lippold, Anna; Morris, Adam; Nabe-Nielsen, Jacob; Nielsen, Nynne H.; Peacock, Elizabeth E.; Rigét, Frank F.; Rosing-Asvid, Aqqalu; Routti, Heli Anna Irmeli; Siebert, Ursula; Stenson, Garry; Stern, Gary; Strand, Jakob; Søndergaard, Jens; Treu, Gabriele; Víkingsson, Gisli A.; Wang, Feiyue; Welker, Jeffrey M.; Wilson, Simon J.; Sonne, Christian (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-16)
      There has been a considerable number of reports on Hg concentrations in Arctic mammals since the last Arctic Monitoring and Assessment Programme (AMAP) effort to review biological effects of the exposure to mercury (Hg) in Arctic biota in 2010 and 2018. Here, we provide an update on the state of the knowledge of health risk associated with Hg concentrations in Arctic marine and terrestrial mammal ...
    • Seroprevalence for Brucella spp. in Baltic ringed seals (Phoca hispida) and East Greenland harp (Pagophilus groenlandicus) and hooded (Cystophora cristata) seals 

      Sonne, Christian; Andersen-Ranberg, Emilie; Rajala, Elisabeth; Agerholm, Jørgen S.; Bonefeld-Jørgensen, Eva; Desforges, Jean-Pierre; Eulaers, Igor; Jenssen, Bjørn Munro; Koch, Anders; Rosings-Asvid, Aqqualu; Siebert, Ursula; Tryland, Morten; Mulvad, Gert; Härkönen, Tero; Acquarone, Mario; Nordøy, Erling Sverre; Dietz, Rune; Magnusson, Ulf (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-12)
      Zoonotic infections transmitted from marine mammals to humans in the Baltic and European Arctic are of unknown significance, despite given considerable potential for transmission due to local hunt. Here we present results of an initial screening for <i>Brucella</i> spp. in Arctic and Baltic seal species. Baltic ringed seals (<i>Pusa hispida</i>, n = 12) sampled in October 2015 and Greenland Sea harp ...
    • Temporal trends of persistent organic pollutants in Barents Sea polar bears (Ursus maritimus) in relation to changes in feeding habits and body condition 

      Lippold, Anna; Bourgeon, Sophie; Aars, Jon; Andersen, Magnus; Polder, Anuschka; Lyche, Jan Ludvig; Bytingsvik, Jenny; Jenssen, Bjørn Munro; Derocher, Andrew E.; Welker, Jeffrey Martin; Routti, Heli (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-14)
      Temporal trends of persistent organic pollutants (POPs: PCBs, OH-PCBs, <i>p,p′</i>-DDE, HCB, β-HCH, oxychlordane, BDE-47, and 153) in relation to changes in feeding habits and body condition in adult female polar bears (<i>Ursus maritimus</i>) from the Barents Sea subpopulation were examined over 20 years (1997–2017). All 306 samples were collected in the spring (April). Both stable isotope values ...